Article: Vitamin C nutriture has little short-term effect on vitamin E concentrations in healthy women

ABSTRACT To determine whether the postulated sparing effect of vitamin E by ascorbic acid (AA) is important for human nutrition, we studied vitamin E status in 20 healthy pre-menopausal women (age 2043 y) with high or low vitamin C intakes for 6 wk in a live-in metabolic unit. The experimental diet contained no fruits and vegetables and provided 5 mg/d of AA (Recommended Dietary Allowance = 60 mg/d), 3 mg/ d of a-tocopherol (RDA = 10 mg/d) and 42 g/d of tocopherol-stripped safflower oil to increase the vitamin E requirement. Half of the subjects received a daily AA supplement of 495 mg (high AA group). A biochemical ascorbate deficiency was attained in the low AA group as indicated by ...

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