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Article: Ascorbic acid deficiency reduces hepatic apolipoprotein A-I mRNA in scurvy-prone ODS rats
- Article from:
- The Journal of Nutrition
- Article date:
- October 1, 1996
- Author:
CopyrightCopyright American Institute of Nutrition Oct 1996. Provided by ProQuest LLC. (Hide copyright information)
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Plasma lipoproteins play key roles in cholesterol transport and hence in the progress of atherosclerotic coronary diseases. Low density lipoprotein is thought to carry cholesterol to peripheral tissues, and HDL functions in the reverse cholesterol transport (Fielding and Fielding 1995, Fisher et al. 1989). Therefore, LDL is regarded as a positive risk factor for coronary diseases, whereas a high level of plasma HDL is believed to reduce the risk. Apolipoprotein A-I lapo A-I) is a major constituent protein of HDL and is also involved in the activation of the enzyme lecithin:cholesterol acyl transferase (EC 2.3.1.43) (Fielding et al. 1972). Numerous studies in humans (Maciejko et al. 1983, ...
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