Article: The long-term impact of 2-3 years of hormone replacement therapy on cardiovascular mortality and atherosclerosis in healthy women

Key words: HORMONE REPLACEMENT THERAPY, CARDIOVASCULAR DISEASE, MORTALITY, ATHEROSCLEROSIS, WOMEN

ABSTRACT

Objective The effect of hormone replacement therapy (HRT) on cardiovascular risk is intensely debated. The aim of this study was to investigate the long-term effects of HRT given for a few years on all-cause and cardiovascular mortality and the severity of atherosclerosis.

Methods This analysis was based on a cohort of 1458 postmenopausal women (55.8 ± 6.1 years old) who previously participated in a number of randomized, placebo-controlled, clinical trials assessing the efficacy of 2-3 years of therapy with various estrogen plus progestin combinations for preventing bone loss. Women ...

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