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Article: Modeling the Effects of HER/ErbB1-3 Coexpression on Receptor Dimerization and Biological Response
- Article from:
- Biophysical Journal
- Article date:
- June 1, 2006
- Author:
CopyrightCopyright Biophysical Society Jun 1, 2006. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
The human epidermal growth factor receptor (HER/ErbB) system comprises the epidermal growth factor receptor (EGFR/HER1) and three other homologs, namely HERs 2-4. This receptor system plays a critical role in cell proliferation and differentiation and receptor overexpression has been associated with poor prognosis in cancers of the epithelium. Here, we examine the effect of coexpressing varying levels of HERs 1-3 on the receptor dimerization patterns using a detailed kinetic model for HER/ErbB dimerization and trafficking. Our results indicate that coexpression of EGFR with HER2 or HER3 biases signaling to the cell surface and retards signal downregulation. In addition, ...