Articles > Journals > Applied Sciences journals > Biophysical Journal articles > June 2006

Article: Modeling the Effects of HER/ErbB1-3 Coexpression on Receptor Dimerization and Biological Response

Article from:
Biophysical Journal
Article date:
June 1, 2006
Author:
Copyright

ABSTRACT

The human epidermal growth factor receptor (HER/ErbB) system comprises the epidermal growth factor receptor (EGFR/HER1) and three other homologs, namely HERs 2-4. This receptor system plays a critical role in cell proliferation and differentiation and receptor overexpression has b een associated with poor prognosis in cancers of the epithelium. Here, we examine the effect of coexpressing varying levels of HERs 1-3 on the receptor dimerization patterns using a detailed kinetic model for HER/ErbB dimerization and trafficking. Our results indicate that coexpression of EGFR with HER2 or HER3 biases signaling to the cell surface and retards signal downregulation. In addition, ...

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