Articles > Journals > Applied Sciences journals > Biophysical Journal articles > June 2006

Article: Modeling the Effects of HER/ErbB1-3 Coexpression on Receptor Dimerization and Biological Response

Article from:
Biophysical Journal
Article date:
June 1, 2006
Author:
Copyright

ABSTRACT

The human epidermal growth factor receptor (HER/ErbB) system comprises the epidermal growth factor receptor (EGFR/HER1) and three other homologs, namely HERs 2-4. This receptor system plays a critical role in cell proliferation and differentiation and receptor overexpression has been associated with poor prognosis in cancers of the epithelium. Here, we examine the effect of coexpressing varying levels of HERs 1-3 on the receptor dimerization patterns using a detailed kinetic model for HER/ErbB dimerization and trafficking. Our results indicate that coexpression of EGFR with HER2 or HER3 biases signaling to the cell surface and retards signal downregulation. In addition, ...

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