|
|
Article: Rare Variant of Apolipoprotein E (Arg136[arrow right]Ser) in Two Normolipidemic Individuals
- Article from:
- Physiological Research
- Article date:
- September 1, 2005
- Author:
CopyrightCopyright Institute of Physiology 2005. Provided by ProQuest LLC. (Hide copyright information)
|
Summary
Through the analysis of the common apolipoprotein (apo) E gene polymorphism in large Caucasian population study with the PCR and subsequent restriction analysis, we have identified carriers of mutant allele Arg 136[arrow right]Ser. Both of them (71-years-old female and her 43-years-old son) have normal lipid parameters. We suggest that Arg136[arrow right]Ser mutation in apoE is not necessarily connected with elevated lipid levels in all cases. Furthermore, so far unidentified factors (environmental and/or genetic) are important for the development of lipid metabolism disorders in apoE Arg136[arrow right]Ser mutation carriers.
Key words
Apolipoprotein E * Rare mutation * Lipid ...