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Article: Radiolabeled amino acids: Basic aspects and clinical applications in oncology
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- March 1, 2001
- Author:
CopyrightCopyright Society of Nuclear Medicine Mar 2001. Provided by ProQuest LLC. (Hide copyright information)
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Radiolabeled Amino Acids: Basic Aspects and
Clinical Applications in Oncology*
As the applications of metabolic imaging are expanding, radiolabeled amino acids may gain increased clinical interest. This review first describes the basic aspects of amino acid metabolism, then contin
ues with basic aspects of radiolabeled amino acids, and finally describes clinical applications, with an emphasis on diagnostic value. A special focus is on ^sup 11^C-methionine, ^sup 11^C-tyrosine, and ^sup 123^I-iodomethyltyrosine, because these have been most used clinically, although their common affinity for the L-transport systems may limit generalization to other classes of amino acids. The theoretic and ...