|
|
Article: First Evaluation of a ^sup 99m^Tc-Tricarbonyl Complex, ^sup 99m^Tc(CO)^sub 3^(LAN), as a New Renal Radiopharmaceutical in Humans
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- June 1, 2006
- Author:
CopyrightCopyright Society of Nuclear Medicine Jun 2006. Provided by ProQuest LLC. (Hide copyright information)
|
^sup 99m^Tc-Mercaptoacetyltriglycine (^sup 99m^Tc-MAG3), ^sup 99m^Tc-DD- and LL-ethylene-dicysteine (^sup 99m^Tc-EC), and ^sup 99m^Tc-mercaptoacetamide-ethylene-cysteine (^sup 99m^Tc-MAEC) contain N^sub 3^S or N^sub 2^S^sub 2^ ligands designed to accommodate the 4 ligating sites of the (^sup 99m^TcO)^sup 3+^ core; they are all excellent renal imaging agents but have renal clearances lower than that of ^sup 131^I-orthoiodohippurate (^sup 131^I-OIH). To explore the potential of the newly accessible but less polar [^sup 99m^Tc(CO)^sub 3^]^sup +^ core with 3 ligating sites, we decided to build on the success of ^sup 99m^Tc-EC, with its N^sub 2^S^sub 2^ ligand and 2 dangling carboxylate groups; ...