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Article: Skeletal unloading and dietary copper depletion are detrimental to bone quality of mature rats

Article from:
The Journal of Nutrition
Article date:
February 1, 2002
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Skeletal Unloading and Dietary Copper Depletion Are Detrimental to Bone Quality of Mature Rats1

ABSTRACT This study was designed to examine the skeletal response to copper depletion and mechanical unloading in mature animals. In a 2 x 2 experimental design, 5.5-mo-old male Sprague-Dawley rats (n = 36) consumed either the control (AIN-93M) or Cu-depletion (-Cu) diet beginning 21 d before suspension and throughout the remainder of the study. Half of the rats in each dietary treatment group were either tail-suspended (TS) or kept ambulatory (AMB) for 28 d. Lower bone mineral densities (BMD) of 5th lumbar vertebra (L5) (P < 0.05) and femur were observed with -Cu and TS, but no differences ...

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