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Article: Regional Cerebral Glucose Metabolic Abnormality in Prader-Willi Syndrome: A ^sup 18^F-FDG PET Study Under Sedation

Article from:
The Journal of Nuclear Medicine
Article date:
July 1, 2006
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Prader-Willi syndrome (PWS) is a genetic disorder caused by the nonexpression of paternal genes in the PWS region of chromosome 15q11-13 and is the most common cause of human syndromic obesity. Methods: We investigated regional brain metabolic impairment in children with PWS by ^sup 18^F-FDG PET. Sixteen children with PWS (9 males, 7 females; mean age ± SD, 4.2 ± 1.1 y) and 7 healthy children (4 males, 3 females; mean age ±+ SD, 4.0 ± 1.7 y) underwent brain ^sup 18^F-FDG PET in the resting state. The images of PWS children were compared using statistical parametric mapping analysis with those of healthy children in a voxelwise manner. Results: Group comparison showed that children with ...

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