Article: Reproducibility of Measurements of Regional Myocardial Blood Flow in a Model of Coronary Artery Disease: Comparison of H^sub 2^^sup 15^O and ^sup 13^NH^sub 3^ PET Techniques

PET absolute myocardial blood flow (MBF) with H^sub 2^^sup 15^O and ^sup 13^NH^sub 3^ are widely used in clinical and research settings. However, their reproducibility with a 16-myocardial segment model has not been examined in chronic coronary artery disease (CAD). We examined the short-term reproducibility of PET H^sub 2^^sup 15^O MBF and PET ^sup 13^NH^sub 3^ MBF in an animal model of chronic CAD. Methods: Twelve swine (mean weight ± SD, 38 ± 5 kg) underwent percutaneous placement of a copper stent in the mid circumflex coronary artery, resulting in an intense inflammatory fibrotic reaction with luminal stenosis at 4 wk. Each animal underwent repeated resting MBF measurements by PET ...

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