Article: Indiplon: A short-acting GABA-A receptor agonist sedative hypnotic for the treatment of insomnia

Abstract

A number of clinical approaches are utilized in managing insomnia. Indiplon (Pfizer) is a selective non-benzodiazepine sedative hypnotic under consideration by FDA for the treatment of insomnia. Like other agents in its class, indiplon binds selectively to the GABA-A receptors in the brain, promoting sleep. Clinical studies have demonstrated improved efficacy in the treatment of sleep initiation and sleep maintenance with indiplon therapy in patients with acute and chronic insomnia. (Formulary. 2006;41:316-321.)

More than a third of American adults have experienced occasional insomnia or sleep disruption.1 Insomnia is a common disorder characterized by difficulty falling asleep, ...

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