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Article: Lipid Infusion Accelerates Removal of Bupivacaine and Recovery From Bupivacaine Toxicity in the Isolated Rat Heart
- Article from:
- Regional Anesthesia and Pain Medicine
- Article date:
- July 1, 2006
- Author:
CopyrightCopyright Churchill Livingstone Inc., Medical Publishers Jul/Aug 2006. Provided by ProQuest LLC. (Hide copyright information)
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Background and Objectives: Infusion of a lipid emulsion has been advocated for treatment of severe bupivacaine cardiac toxicity. The mechanism of lipid rescue is unknown. These studies address the possibility that lipid infusion reduces cardiac bupivacaine content in the context of cardiac toxicity.
Methods: We compared the effects of a 1% lipid emulsion with standard Krebs buffer after inducing asystole in isolated rat heart vvilh 500 µmol/L bupivacaine. We compared times to first heart beat and recovery of 90% of baseline rate pressure product (RPP = heart rate à [left ventricular systolic pressure - left ventricular diastolic pressure]) between controls and hearts receiving 1% lipid ...