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Article: Blood flow and metabolism in locally advanced breast cancer: Relationship to response to therapy
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- April 1, 2002
- Author:
CopyrightCopyright Society of Nuclear Medicine Apr 2002. Provided by ProQuest LLC. (Hide copyright information)
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Locally advanced breast cancer (LABC) is commonly treated with neoadjuvant chemotherapy followed by definitive surgery. The factors influencing the response of LABC to presurgical chemotherapy are incompletely understood. To characterize in vivo tumor biology in patients with LABC, we measured pretherapy blood flow and glucose metabolism in LABC, compared measurements with clinical and pathologic parameters, and examined blood flow and response to subsequent neoadjuvant chemotherapy. Methods: Thirty-seven patients with newly diagnosed LABC underwent ^sup 18^F-FDG and ^sup 15^O-water PET imaging. Thirty-one of these patients underwent neoadjuvant chemotherapy, and response was evaluated by ...