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Article: Local Anesthetics in Lipid-Depot Formulations-Neurotoxicity in Relation to Duration of Effect in a Rat Model
- Article from:
- Regional Anesthesia and Pain Medicine
- Article date:
- September 1, 2006
- Author:
CopyrightCopyright Churchill Livingstone Inc., Medical Publishers Sep/Oct 2006. Provided by ProQuest LLC. (Hide copyright information)
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Background and Objectives: The aim of this study was to investigate the possible local neurotoxicity of a number of lipid-depot formulations of local anesthetics in relation to their duration of action in sciatic-nerve block.
Methods: Formulations that contain 2%, 4%, 8%, 16%, 32%, or 64% of a mixture of bupivacaine and lidocaine base 4:1 in medium-chain triglyceride were prepared and evaluated, together with 0.5%, 1.0%, and 2.0% bupivacaine HCl solutions, bupivacaine 4.2% or 7.0% in medium-chain triglyceride, and 20% lidocaine base in a polar lipid vehicle. The duration of sensory and motor sciatic-nerve block was determined in rats. A week later, the sciatic nerves were dissected and ...