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Article: Vitamin C Deficiency Increases the Lung Pathology of Influenza Virus-Infected Gulo-/- Mice1
- Article from:
- The Journal of Nutrition
- Article date:
- October 1, 2006
- Author:
CopyrightCopyright American Institute of Nutrition Oct 2006. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
This study was designed to determine the effects of vitamin C deficiency on the immune response to infection with influenza virus. L-Gulono-γ-lactone oxidase gene-inactivated mice (gulo-/- mice) require vitamin C supplementation for survival. Five-wk-old male and female gulo-/- mice were provided water or water containing 1.67 mmol/L vitamin C for 3 wk before inoculation with influenza A/Bangkok/1/79. There were no differences in lung influenza virus titers between vitamin C-adequate and -deficient mice; however, lung pathology in the vitamin C-deficient mice was greater at 1 and 3 d after infection but less at d 7 compared with vitamin C-adequate mice. Male vitamin ...