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Article: Oxygen-15-water PET assessment of muscular blood flow in peripheral vascular disease
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- January 1, 1997
- Author:
CopyrightCopyright Society of Nuclear Medicine Jan 1997. Provided by ProQuest LLC. (Hide copyright information)
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To assess quantitatively regional nutritive muscular blood flow in patients with peripheral vascular disease (PVD), we evaluated the utility of PET with ^sup 15^O-water. Methods: Eight healthy volunteers and 16 patients with angiographically proven PVD were studied. Regional blood flow of the calf was measured with ^sup 15^O-water PET during rest, after intra-arterial infusion of prostaglandin El and during ergometry. The studies were quantified using a one tissue compartment model. Results: Normalized mean tracer uptake from 15-60 sec correlated closely (r = 0.98) with absolute blood flow. Scan times longer than 90 sec were required to determine blood flow reliably. The flow values were ...
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