Article: Oxygen-15-water PET assessment of muscular blood flow in peripheral vascular disease

To assess quantitatively regional nutritive muscular blood flow in patients with peripheral vascular disease (PVD), we evaluated the utility of PET with ^sup 15^O-water. Methods: Eight healthy volunteers and 16 patients with angiographically proven PVD were studied. Regional blood flow of the calf was measured with ^sup 15^O-water PET during rest, after intra-arterial infusion of prostaglandin El and during ergometry. The studies were quantified using a one tissue compartment model. Results: Normalized mean tracer uptake from 15-60 sec correlated closely (r = 0.98) with absolute blood flow. Scan times longer than 90 sec were required to determine blood flow reliably. The flow values were ...

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