Article: Transport of NGFs plus/minus MIF-1 into spinal cord

PURPOSE-Severe damage to the spinal cord has devastating consequences because of the lack of regeneration of the severed neural pathways. Experimental evidence now exists that axonal regrowth can be stimulated so as to re-establish supraspinal connections of the isolated segments to provide function.

In order to accomplish this regeneration of the spinal cord, an adequate supply of nerve growth factors (NGFs) of the neurotrophin family of small polypeptide proteins is required. Penetration of such substances from the circulation into the spinal cord would open up new approaches to treatment of injuries of the spinal cord.

Until relatively recently, the possibility that NGFs administered ...

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