Common Heart Surgery Drug Potentially Dangerous.

Ascribe Higher Education News Service;  March 25, 2003 ;     745 words ......ORLEANS, March 25 (AScribe Newswire) -- Protamine, a drug used for more than 40 years immediately...pressure changes that often occur with protamine's use are associated with increased mortality...spur development of alternatives for protamine. Protamine, a drug purified from salmon...

Recent experiences with hexadimethrine for neutralizing heparin after...

Anaesthesia and Intensive Care;  June 1, 1999 ;   Cooney, A; Mann, T J;   787 words ......for patients who may be allergic to protamine. In view of the recent renewal of interest...ANTICOAGULANTS: hexadimethrine bromide, protamine, adverse cardiovascular reactions, heparin neutralization Protamine is usually used for neutralization...

prot-

The Oxford American College Dictionary;      13 words ...prot- • comb. form variant spelling of proto- before a vowel (as in protamine ).

IBEX Technologies Inc.: Neutralisation of SR90107 by Neutralase(TM).

Canadian Corporate News;  June 6, 2001 ;     447 words ......data comparing IBEX's Neutralase, to protamine, the only drug currently available for...immunological response than that associated with protamine. The activation of complement during...with a wide range of adverse effects. Protamine administered to reverse heparin at the...

Heart-bypass drug almost runs out

The Press;  May 25, 2006 ;   HAYMAN, Kamala;   331 words ......drug. New Zealand's sole supplier of protamine sulphate -- an essential drug in heart-bypa...months, preserving diminishing supplies of protamine for emergencies. The drug was vital to...In a letter to Christchurch Hospital, protamine supplier Artex Ltd said Australia, Britain...

protamine

A Dictionary of Chemistry;      43 words ...protamine Any of a group of proteins of relatively low molecular weight found in association with the chromosomal DNA of vertebrate sperm cells. They contain a single polypeptide chain comprising about 67%arginine. Protamines are thought to protect and support the chromosomes.

IBEX to Resume Phase III Testing of Neutralase(TM).

PR Newswire;  October 28, 1998 ;     497 words ......compared a low dose of Neutralase to protamine (the current standard of care), due to...changes in blood pressure compared to protamine. The Neutralase group saw significantly...hemodynamic benefit of Neutralase over protamine was clear and warrants further study...

IBEX Technologies Inc.: First Use of Neutralase Following Congenital Heart...

Canadian Corporate News;  June 26, 2001 ;     410 words ......female, previously had a severe reaction to protamine, the drug usually used to reverse the effects...Based on the patient's prior reaction to protamine, the surgical team ruled out the use of protamine, and Neutralase was considered to be the...

TODAY AT AHA CONFERENCE, DR. DEHMER REPORTS CARDIAC DRUG DEMONSTRATES...

PR Newswire;  November 16, 1995 ;     531 words ......Comparison of Platelet Factor-4 Versus Protamine to Reverse Heparin Anticoagulation, during...This Phase II comparison of rPF4 versus protamine was performed in 81 patients having diagnostic...received rPF4 (1mg/kg) over 2 minutes or protamine (50mg) over 10 minutes in a double blinded...

Glyko Biomedical Ltd.'S 27%-Owned Affiliate, BioMarin To Acquire Enzyme...

Canadian Corporate News;  October 10, 2001 ;     787 words ......developed for these indications. Currently, protamine is the only product commercially available...reversal of heparin anticoagulation. Protamine has continued to be used in the absence...the hemodynamic changes associated with protamine. Additional data suggest that Neutralase...

FutureFund Investee Company BioMarin to Proceed with Neutralase Phase III...

Canadian Corporate News;  October 1, 2002 ;     396 words ......complications arising from blood clotting, and protamine is used after surgery to reverse the...heparin to prevent excessive bleeding. Protamine has been associated with systemic hypotension...non-inferiority of Neutralase compared to protamine, based on cumulative chest tube drainage...

Cytochemical and immunocytochemical studies of the localization of...

Folia Histochemica et Cytobiologica;  October 1, 2007 ;   Poplonska, Katarzyna; Wojtczak, Agnieszka; Kwiatkowska, Maria; Kazmierczak, Andrzej;   787 words ......the exchange of histone proteins into protamine-like proteins. Cytochemical studies showed...spV-VIII phases - the amount of nuclear protamine-type proteins progressively increased...histones decreased while at spIX-X only protamine-type proteins were present. This was...

protamine sulfate

The Mosby Medical Encyclopedia;      104 words ...The Mosby Medical Encyclopedia 10-01-1996 protamine sulfate /pr'tumn/, a drug produced from fish sperm used to lower or reverse the effect of an overdose from a drug used to block...

protamine zinc insulin suspension

The Mosby Medical Encyclopedia;      71 words ...The Mosby Medical Encyclopedia 10-01-1996 protamine zinc insulin suspension, a long-acting insulin that is absorbed slowly at a steady rate. Some patients can be treated with only...

Lilly to Release Vial Form of Humalog(R) Mix75/25(TM) (75 Insulin Lispro...

PR Newswire;  December 18, 2000 ;     398 words ......Dec. 18 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) announced today that Humalog(R) Mix75/25(TM) (75 insulin lispro protamine suspension, 25 insulin lispro injection (rDNA origin)), an insulin mixture containing the rapid-acting insulin Humalog(R...