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Bispectral Index Guided Timing of Intubation without Neuromuscular Blockade during Sevoflurane Induction of Anaesthesia in Adults

SUMMARY

The aim of this study was to assess the effectiveness ofbispectral index monitoring (BIS) as a guide to the timing of intubation during sevoflurane induction of anaesthesia without the use of neuromuscular blocking agents in adults, and specifically, whether a target BIS value of 25 provides better intubating conditions than a target BIS of 40.

Forty patients were randomized into one of two groups, a target BIS 25 (n=21) or a target BIS 40 (n=19). Patients received premedication with midazolam 20 µg/kg and fentanyl 0.5 µg/kg. Sevoflurane induction of anaesthesia was initiated and titrated to reach the target BIS value and maintained within the target range for two minutes. The ...

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