Article: Small changes in essential amino acid concentrations alter diet selection in amino acid-deficient rats

ABSTRACT The rat's sensitivity to changes in the dietary limiting amino acid concentration (LAA) was examined on the basis of dietary selection. Rats were adapted to purified low protein basal (Basal) diets in which threonine (Thr) was the LAA (0.188-0.212% wt/wt of diet). In Experiment 1, rats made a clear selection for their adaptation diet over a diet containing 0.012% less threonine after 2-3 d of choice. Rats made no clear dietary selection when given a choice between their adaptation diet and a diet containing 0.012% more threonine. Experiment 2 was conducted to examine the rat's sensitivity to small decreases in the LAA concentration. Rats adapted to a 0.200% Thr-Basal diet clearly ...

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