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Article: Effect of Pongamia pinnata flowers on blood glucose and oxidative stress in alloxan induced diabetic rats
- Article from:
- Indian Journal of Pharmacology
- Article date:
- January 1, 2006
- Author:
CopyrightCopyright Medknow Publications Jan/Feb 2006. Provided by ProQuest LLC. (Hide copyright information)
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Diabetes mellitus is a major metabolic syndrome characterized by derangement in carbohydrate metabolism associated with defect in insulin secretion or action. Alloxan is widely used to induce diabetes mellitus in experimental animals, owing to its ability to destroy the β-cells of pancreas possibly by generating excess reactive oxygen species.[1] Free radical-mediated biomembrane lipid peroxidation has been implicated in the pathogenesis of many pathological conditions including diabetes mellitus and its complications. Overproduction of lipid peroxidation by-products and insufficient antioxidant potential have been reported in both experimental and human diabetes mellitus.[2]
Medicinal ...