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Cultured neural networks: Optimization of patterned network adhesiveness and characterization of their neural activity

Abstract: One type of future, improved neural interface is the "cultured probe". It is a hybrid type of neural information transducer or prosthesis, for stimulation and/or recording of neural activity. It would consist of a microelectrode array (MEA) on a planar substrate, each electrode being covered and surrounded by a local circularly confined network ("island") of cultured neurons. The main purpose of the local networks is that they act as biofriendly intermediates for collateral sprouts from the in vivo system, thus allowing for an effective and selective neuron-electrode interface. As a secondary purpose, one may envisage future information processing applications of these ...

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