Article: Varenicline (Chantix(TM)) Effective for Smoking Cessation

Clinical question

Is varenicline more effective than bupropion and placebo for smoking cessation?

Bottom line

Varenicline (Chantix(TM)) therapy for 12 weeks is significantly more effective than placebo at maintaining smoking abstinence at 52 weeks. Varenicline may also be marginally more effective than bupropion SR. Reported success rates are likely to be higher than real-world settings. (LOE = 1b)

Study Design

Randomized controlled trial (double-blinded)

Funding

Industry

Allocation

Concealed

Setting

Population-based

Synopsis

Varenicline is a nicotinic acetylcholine receptor partial agonist that may reduce the reinforcing effects of nicotine for maintaining smoking behavior. The ...

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