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Article: Enhancement of Proopiomelanocortin Gene Promoter Activity by Local Anesthetics in a Pituitary Cell Line

Article from:
Regional Anesthesia and Pain Medicine
Article date:
January 1, 2007
Author:
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Background and Objectives: Corticotropin-releasing hormone (CRH) induces gene expression of proopiomelanocortin, a precursor protein of adrenocorticotropic hormone and β-endorphin, by elevating intracellular cyclic adenosine 3',5'-monophosphate (cyclic AMP) level in anterior pituitary cells and immune cells. CRH-induced proopiomelanocortin gene expression plays an important role in stress responses and is affected by a variety of drugs, but it is not known whether local anesthetics can directly affect the gene expression. We hypothesized that local anesthetics may directly affect proopiomelanocortin gene expression and can modulate production of adrenocorticotropic hormone and ...

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