Article: Risk Assessment at the USEPA: The Science Behind the Assessments

INTRODUCTION

Many interesting science presentations and discussion of issues regarding uncertainty factors, extrapolation (e.g., from animals to humans, from high to low dose), and new methods for risk assessment (e.g., physiologically based pharmacokinetic models, biologically based dose-response models) occurred during the 2-day Board of Scientific Counselors (BOSC) Workshop on USEPA's Risk Assessment Principles and Practices (February 2-3, 2005). These discussions were stimulated in part by a staff paper on USEPA's Risk Assessment Principles and Practices that was completed in early 2004 by the USEPA Office of the Science Advisor. Importantly, there is a context for this staff paper and ...

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