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Article: Embryo-fetal toxicity signals for 17[alpha]-hydroxyprogesterone caproate in high-risk pregnancies: A review of the non-clinical literature for embryo-fetal toxicity with progestins
- Article from:
- Journal of Maternal - Fetal & Neonatal Medicine
- Article date:
- February 1, 2007
- Author:
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Copyright informationCopyright Taylor & Francis Ltd. Feb 2007. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
Objective. A large National Institutes of Health (NIH) study showed that pharmacy-compounded 17α-hydroxyprogesterone caproate (17-OHP-C) reduced the incidence of preterm birth. The study results included a signal that 17-OHP-C may be associated with an increase in the rate of
miscarriages and stillbirths. The most probable cause of an increased incidence of miscarriage/stillbirths may be the use of 17-OHP-C in high-risk patients. The current search of the non-clinical literature was performed to identify whether there were any signals from studies in animals that might suggest concerns for the safe use of progestins generally, and 17-OHP-C specifically, in the prevention of ...
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Article: Medicolegal issues in preterm birth of multiples.(Obstetrics)
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March 1, 2006 ;
644 words
......said medicolegal issues related to preterm birth in multifetal pregnancies tend to fall...been shown to help improve outcomes in preterm birth, and the American College of Obstetricians...two measures to estimate the risk of preterm birth, Dr. Belfort said at the meeting, which...
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