Article: Embryo-fetal toxicity signals for 17[alpha]-hydroxyprogesterone caproate in high-risk pregnancies: A review of the non-clinical literature for embryo-fetal toxicity with progestins

Abstract

Objective. A large National Institutes of Health (NIH) study showed that pharmacy-compounded 17α-hydroxyprogesterone caproate (17-OHP-C) reduced the incidence of preterm birth. The study results included a signal that 17-OHP-C may be associated with an increase in the rate of miscarriages and stillbirths. The most probable cause of an increased incidence of miscarriage/stillbirths may be the use of 17-OHP-C in high-risk patients. The current search of the non-clinical literature was performed to identify whether there were any signals from studies in animals that might suggest concerns for the safe use of progestins generally, and 17-OHP-C specifically, in the prevention of ...

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