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Article: Antimicrobial resistance profile of Pseudomonas aeruginosa producing metallo-[beta]-lactamases
- Article from:
- Indian Journal of Medical Research
- Article date:
- November 1, 2006
- Author:
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Copyright informationCopyright Indian Council of Medical Research Nov 2006. Provided by ProQuest LLC. (Hide copyright information)
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Sir,
A growing number of infections due to multi-drug resistant (MDR) Pseudomonas aeruginosa producing metallo-β-lactamases (MβLs) is worrisome. Such strains are resistant to most broad spectrum β-lactams, aminoglycosides, and fluoroquinolones - the traditional antipseudomonal antimicrobials1. Hence there is a renewed interest in non-traditional agents including polymyxin B and E (colistin) for the treatment of serious MDR P. aeruginosa infections.
The polymyxins are polypeptide antibiotics exerting their bactericidal activity by disrupting membrane permeability and anti-endotoxicity2. Almost four decades ago they were amongst the few parenteral agents available for serious ...