Article: Antimicrobial resistance profile of Pseudomonas aeruginosa producing metallo-[beta]-lactamases

Sir,

A growing number of infections due to multi-drug resistant (MDR) Pseudomonas aeruginosa producing metallo-β-lactamases (MβLs) is worrisome. Such strains are resistant to most broad spectrum β-lactams, aminoglycosides, and fluoroquinolones - the traditional antipseudomonal antimicrobials1. Hence there is a renewed interest in non-traditional agents including polymyxin B and E (colistin) for the treatment of serious MDR P. aeruginosa infections.

The polymyxins are polypeptide antibiotics exerting their bactericidal activity by disrupting membrane permeability and anti-endotoxicity2. Almost four decades ago they were amongst the few parenteral agents available for serious ...

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