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Article: Lowering Homocysteine with B Vitamins Has No Effect on Blood Pressure in Older Adults1,2
- Article from:
- The Journal of Nutrition
- Article date:
- May 1, 2007
- Author:
CopyrightCopyright American Institute of Nutrition May 2007. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
An elevated circulating homocysteine concentration is associated with the risk of cardiovascular disease. The mechanism by which an elevated homocysteine increases cardiovascular risk is unclear but may be mediated in part by elevating blood pressure. It is well established that supplements containing folate, vitamins B-12, and B-6 lower homocysteine concentrations. However, the effect of homocysteme-lowering vitamins on blood pressure has not been well studied. We sought to determine whether lowering homocysteine with B vitamins lowers blood pressure in healthy older people with elevated homocysteine concentrations. Two hundred seventy-six healthy older participants (≥65 y) ...