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Article: Expression of glucocorticoid receptors and cyclooxygenase-2 in nasal polyps from nonallergic patients
- Article from:
- The Annals of Otology, Rhinology & Laryngology
- Article date:
- January 1, 2002
- Author:
CopyrightCopyright Annals Publishing Company Jan 2002. Provided by ProQuest LLC. (Hide copyright information)
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Glucocorticoid treatment has been widely used to suppress inflammatory and immune responses. However, from a clinical point of view, its efficacy in the treatment of nasal polyposis seems to vary individually from patient to patient. In the present study, we examined the presence of glucocorticoid receptors (GRs) and cyclooxygenase-2 (COX-2) in the nasal polyps of nonallergic patients as compared with normal controls. Reverse transcription-polymerase chain reaction analyses revealed the presence of both GR messenger RNA and COX-2 messenger RNA expression in nasal polyps from nonallergic patients, as well as in normal nasal mucosa from controls. Consistent with this finding, ...
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