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Article: Study of Immune Cells Involved in the Antitumor Effect of Kefir in a Murine Breast Cancer Model
- Article from:
- Journal of Dairy Science
- Article date:
- April 1, 2007
- Author:
CopyrightCopyright American Dairy Science Association Apr 2007. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Administration of kefir and a kefir cell-free fraction (KF) to mice injected with breast tumor cells produced, locally in the mammary gland, different profiles of cells secreting cytokines. Here, the immune cell populations in mammary glands affected by the cyclic consumption of kefir or KF for 2 or 7 d were evaluated using a breast tumor model. Apoptosis was also assayed as another mechanism involved in tumor growth delay. The rate development of tumor cells, IgA(+) cells, and CD4+ and CD8+ T lymphocytes was monitored in mammary gland tissues. The number of Bcl-2(+) cells in the mammary gland was compared with the apoptosis observed in the tumor. Two-day cyclical administration of ...