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Article: Differentiation of osteoblasts from mouse embryonic stem cells without generation of embryoid body

Article from:
In Vitro Cellular & Developmental Biology
Article date:
January 1, 2007
Author:
Copyright

Received: 16 November 2006 / Accepted: 13 December 2006 / Published online: 9 February 2007 / Editor: J. D3nry Sato

© The Society for In Vitro Biology 2007

Abstract Osteoblasts are cells specialized in extracellular matrix production and mineralization. In collaboration with osteoclasts which are bone-resorbing cells, osteoblasts regulate bone homeostasis. The study of osteoblast differentiation from lhe earliest states of the differentiation can be performed using embryonic stem cells. Embryonic stem cells are pluripolent cells which have the capacity to give rise to all kinds of cells of the body. The main protocol to differentiate embryonic stem cells into osteoblast uses the generation ...

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