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Article: Spatial Heterogeneity of Low-Grade Gliomas at the Capillary Level: A PET Study on Tumor Blood Flow and Amino Acid Uptake
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- July 1, 2007
- Author:
CopyrightCopyright Society of Nuclear Medicine Jul 2007. Provided by ProQuest LLC. (Hide copyright information)
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Many low-grade gliomas (World Health Organization grade II) respond to chemotherapy. Cerebral blood flow (CBF) and microvessel density may be critical for drug delivery. We used PET with ^sup 18^F-fluoro-ethyl-L-tyrosine (FET) to measure the spatial distribution of the amino acid carrier, which is located at the brain capillaries, and ^sup 15^O-H2O to measure tumor CBF. Methods: Seventeen patients with low-grade glioma were studied. Region-of-interest (ROI) analysis was used to quantify tumor tracer uptake, which was normalized to cerebellar uptake (tumor-to-cerebellum ratio). "Active" tumor was defined as tumor having a radioactivity concentration that was at least 110% of the cerebellar ...