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Article: Nuclear Uptake and Dosimetry of ^sup 64^Cu-Labeled Chelator-Somatostatin Conjugates in an SSTr2-Transfected Human Tumor Cell Line
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- August 1, 2007
- Author:
CopyrightCopyright Society of Nuclear Medicine Aug 2007. Provided by ProQuest LLC. (Hide copyright information)
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^sup 64^Cu radiopharmaceuticals have shown tumor growth inhibition in tumor-bearing animal models with a relatively low radiation dose that may be related to nuclear localization of the ^sup 64^Cu in tumor cells. Here we address whether the nuclear localization of ^sup 64^Cu from a ^sup 64^Cu-labeled chelator-somatostatin conjugate is related to the dissociation of the radio-copper from its chelator. The ^sup 64^Cu complex of 1,4,8, 11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid (TETA) has demonstrated instability in vivo, whereas ^sup 64^Cu-CB-TE2A (CB-TE2A is 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane) was highly stable. Methods: Receptor binding, nuclear ...