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Article: Bovine [kappa]-Casein Gene Promoter Haplotypes with Potential Implications for Milk Protein Expression
- Article from:
- Journal of Dairy Science
- Article date:
- September 1, 2007
- Author:
CopyrightCopyright American Dairy Science Association Sep 2007. Provided by ProQuest LLC. (Hide copyright information)
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ABSTRACT
Genetic analysis of the κ-casein gene (CSN3) promoter regions of 42 cattle representing 9 different breeds revealed that 2 distinct haplotypes (A and B) exist at this locus, differing from each other by single base changes at positions -514 (T/G), -426 (T/C), and -384 (T/C), where haplotype A has bases T, T, and T and haplotype B has bases G, C, and C. The AA and AB haplotypes were found to occur at a higher frequency in the animals tested, with 69.0 and 21.4% being homozygous and heterozygous, respectively. The sequences that include these polymorphisms are potentially important in transcriptional regulation of the κ-casein gene, because they contain putative sites for ...