Article: Evidence for histamine involvement in the effect of histidine loads on food and water intake in rats

Evidence for Histamine Involvement in the Effect of Histidine Loads on Food and Water Intake in Rats1,2

Peyman Vaziri, Karen Dang and G. Harvey Anderson3

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto M5S 3E2, Canada

ABSTRACT We examined the hypothesis that histidine is a regulator of short-term food and water intake in rats and that this control is through histidine's action as a precursor for histamine. The primary objectives were to measure food and water intake after histidine monohydrochloride monohydrate (His-HCI) given by intragastric (IG) and intraperitoneal (IP) routes of administration and to measure feeding and drinking responses to ...

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