Article: Massachusetts Inventors Develop Lectin Complement Pathway Regulating Product

Article: In Vivo Data on Taligen Therapeutics' Pipeline Candidates ...
PR Newswire;  October 7, 2008 ;     700+ words ... ... of the alternative complement pathway slowed or halted ... alternative, classical and lectin complement pathways whereas ... targeting the alternative complement pathway, while keeping the classical and lectin complement pathways unaffected ...

Article: Activation of the alternative complement pathway by ...
Phytomedicine: International Journal of Phytotherapy & Phytopharmacology;  September 1, 2002 ;     700+ words ... ... respectively, and were used as stimulants for complement throughout the experiments. As a stimulant for the alternative complement pathway, dextran sulfate (DS; Sigma, USA) was also examined. The molecular weigh of the 5 kinds of DS used ranged ...

Article: Mannan-binding lectin activates C3 and the alternative ...
Journal of Clinical Investigation;  May 1, 2006 ;     700+ words ...Lectin pathway activation of C3 is known to involve target recognition by mannan-binding lectin (MBL) or ficolins and generation of classical pathway C3 convertase via cleavage of C4 and C2 by MBL-associated serine protease 2 (MASP-2). We investigated C3 activation in C2-deficient human sera and in

Article: MBL2 and Hepatitis C Virus Infection among Injection Drug ...
BMC Infectious Diseases;  May 1, 2008 ;     700+ words ... ... fungal, viral, and parasitic pathogens. MBL directly mediates opsonophagocytosis and acvation of the C-type lectin complement pathway by binding microbial mannose and N-acetylglucosamine surface residues. MBL deficiency has been associated ...

Article: Purification of lamprey Mannose-binding lectin and binding to ...
Journal of the Tennessee Academy of Science;  July 1, 2008 ;     700+ words ... ... concentration in lamprey plasma could be important in their innate immunity and resistance to infection. This study describes the presence of MBL in sea lamprey plasma and evidence for a C-type lectin complement pathway of innate immunity.

Article: Chinese medicine uses the seahorse; molecular profiling reveals ...
Drug Week;  November 7, 2003 ;     700+ words ... ... singletons) were examined in the present study. The high prevalence of C-type lectins suggested that a lectin-complement pathway might exert a more dominant function in the innate immune system of teleost than mammal. Carbohydrate recognition ...

Article: Alexion Pharmaceuticals & Brigham and Women's Hospital Scientists ...
PR Newswire;  May 3, 2000 ;     700+ words ... ... other vascular disorders. The paper, entitled "Complement Activation After Oxidative Stress: Role of the Lectin Complement Pathway," resulted from preclinical studies that are part of a collaboration between scientists at Alexion and Brigham ...