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Article: Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone
- Article from:
- Journal of Maternal - Fetal & Neonatal Medicine
- Article date:
- November 1, 2007
- Author:
CopyrightCopyright Taylor & Francis Ltd. Nov 2007. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
Objective. In rats, maternal low protein diet induces growth restriction, increases fetal glucocorticoid exposure and programs cardiovascular and endocrine dysfunction in adult offspring. We hypothesized that both maternal low protein diet and late gestation dexamethasone program murine offspring to develop hypertension, vascular dysfunction, and glucose intolerance.
Methods. An iso-caloric low protein diet (LP) was provided to dams from E0 to E19. Additional dams received a normal protein diet without (NP) or with either dexamethasone (NP-Dex, 0.1 mg/kg/d sc) or normal saline (NP-NS) from E10 to E18.
Results. Offspring of dams given LP weighed less at 10 days than NP offspring, ...