Article: The Healthy Heart Report

Gene Therapy for Angina

Researchers are testing a genetically engineered treatment for women with angina, the piercing chest pain that plagues millions of Americans with heart disease due to insufficient blood flow to the heart muscle. Given fasttrack status by the FDA, the AWARE study will enroll 300 women at up to 50 medical centers in the United States. The women will receive infusion of a harmless virus engineered to carry a gene that promotes the growth and development of new blood vessels, thereby increasing blood flow to the heart muscle. Existing treatments for angina target symptoms of the condition by widening blood vessels, either temporarily with drugs such as nitroglycerin or ...

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