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Article: Effects of elevated glucose levels on interactions of cardiac fibroblasts with the extracellular matrix

Article from:
In Vitro Cellular & Developmental Biology
Article date:
September 1, 2007
Author:
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Abstract Exposure of fibroblasts to high glucose levels promotes a fibrotic response characterized by increased expression of extracellular matrix components including interstitial collagens. Little is known about the effects of glucose levels on other aspects of fibroblast function. Fibroblasts in the myocardium are surrounded by an extensive extracellular matrix composed predominantly of type I collagen. Interactions between fibroblasts and the myocardial extracellular matrix are thought to affect heart function by altering ventricular diastolic properties. The purpose of the present study was to determine the effects of elevated glucose levels on the interactions between heart ...

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