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Article: Processing of Generator-Produced ^sup 68^Ga for Medical Application

Article from:
The Journal of Nuclear Medicine
Article date:
October 1, 2007
Author:
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The ^sup 68^Ge/^sup 68^Ga generator provides an excellent source of positron-emitting ^sup 68^Ga. However, newly available "ionic" ^sup 68^Ge/^sup 68^Ga radionuclide generators are not necessarily optimized for the synthesis of ^sup 68^Ga-labeled radiopharmaceuticals. The eluates have rather large volumes, a high concentration of H+ (pH of 1), a breakthrough of ^sup 68^Ge, increasing with time or frequency of use, and impurities such as stable Zn(II) generated by the decay of ^sup 68^Ga, Ti(IV) as a constituent of the column material, and Fe(III) as a general impurity. Methods: We have developed an efficient route for the processing of generator-derived ^sup 68^Ga eluates, including the ...

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