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Aging: A Genetic Balancing Act

It is now generally accepted that the time-dependent decrease in fitness in most multicellular organisms is nonadaptive-that is, it is not controlled by a purposeful genetic program similar to the control of development. Aging provides no specific advantage to an individual animal, and most researchers now accept that age-related degeneration and death are ultimately due to the greater relative weight placed by natural selection on early survival and reproduction than on maintaining vigor at later ages. This decline in the force of natural selection at later ages is largely due to the scarcity of older individuals in natural populations owing to mortality caused by extrinsic hazards. ...

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