Article: A Receptor-Mediated Mechanism to Support Clinical Observation of Altered Albumin Variants

To the Editor:

Dolcini et al. (1) recently reported in this journal a novel splice-site mutation (denoted Bartin) that causes deletion of exon 11 in the human serum albumin (HSA) gene, ALB. In spite of their uncertain relevance to pathophysiology of diseases, differences in HSA sequence have interesting correlations with functional properties and stability. Bisalbuminemia (or alloalbuminemia) is a rare inherited or acquired condition characterized by the occurrence of 2 circulating components that are observed, typically, during routine clinical electrophoresis or in genetic surveys.

Over the past decades several cases of genetic polymorphisms, described in peer-reviewed papers and listed ...

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