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Article: Progestins and breast cancer
- Article from:
- Gynecological Endocrinology
- Article date:
- October 1, 2007
- Author:
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Copyright informationCopyright Taylor & Francis Ltd. Oct 2007. Provided by ProQuest LLC. (Hide copyright information)
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Abstract
Progestins exert their progestational activity by binding to the progesterone receptor (form A, the most active and form B, the less active) and may also interact with other steroid receptors (androgen, glucocorticoid, mineralocorticoid, estrogen). They can have important effects in other tissues besides the endometrium, including the breast, liver, bone and brain. The biological responses of progestins cover a very large domain: lipids, carbohydrates, proteins, water and electrolyte regulation, hemostasis, fibrinolysis, and cardiovascular and immmunological systems. At present, more than 200 progestin compounds have been synthesized, but the biological response could be different ...
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