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An overview of high-dose melphalan and stem cell transplantation in the treatment of AL amyloidosis

Keywords: AL amyloidosis, treatment, stem cell transplantation, melphalan

Abbreviations: HDM/SCT= high-dose melphalan and stem cell transplantation; CR = hematologic complete response; FLC=serum free light chain concentration; TRM = treatment-related mortality

Abstract

AL amyloidosis is the most common form of systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. This review outlines an overview of high-dose intravenous melphalan and stem cell transplantation in the treatment of AL amyloidosis. An algorithm of our recommendations for the treatment of AL amyloidosis is also outlined.

Introduction

The amyloidoses are a group of diseases that share a common feature ...

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