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Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis
- Article from:
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Amyloid
- Article date:
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December 1, 2007
- Author:
- Mavragani, Clio P; Yiannakouris, Nikos; Zintzaras, Elias; Melistas, Labros; Ritis, Kostas; Skopouli, Fotini N
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Copyright informationCopyright Taylor & Francis Ltd. Dec 2007. Provided by ProQuest LLC. (Hide copyright information)
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Keywords: Rheumatoid arthritis, secondary amyloidosis, SAA1 alleles
Abbreviations: R = rheumatoid arthritis; FMF=familial Mediterranean fever; SAA = serum amyloid A protein
Abstract
Objective. To address whether or not the rarity of amyloidosis in Greek patients with rheumatoid arthritis (RA) is related to specific alleles of single nucleotide polymorphisms (SNPs) in the 5'-flanking region and the exon 3 of the SSA1 gene.
Methods. The genotypes of the -13T/C SNP in the 5'-flanking region of the SAA1 gene and the two SNPs within exon 3 of SAA1 (2995C/T and 3010C/T polymorphisms) were determined in 88 Greek patients with RA, 14 patients with familial Mediterranean fever (FMF) and 110 healthy ...