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Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese
- Article from:
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Amyloid
- Article date:
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December 1, 2007
- Author:
- Mak, Chloe M; Kwong, Yok-Lam; Lam, Ching-Wan; Chan, See-Ching; Lo, Chung-Mau; Fan, Sheung-Tak; Chang, Chee-My; Lau, Yuk-Kwong; U, Lok-Sun; Tam, Sidney
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Copyright informationCopyright Taylor & Francis Ltd. Dec 2007. Provided by ProQuest LLC. (Hide copyright information)
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Keywords: Familial transthyretin amyloidosis, Hong Kong Chinese, TTR gene
Abbreviations: ATTR = Familial transthyretin amyloidosis
Abstract
Familial transthyretin amyloidosis (ATTR), caused by mutant transthyretin deposition, is mainly characterized by peripheral neuropathy, autonomic dysfunction, and cardiomyopathy. There are few reports among the Chinese population. We previously described the TTR mutation (Val30Ala) in the first Hong Kong Chinese family with ATTR. In this study, we report the progress of this family and describe another three unrelated Chinese kinships newly diagnosed with ATTR. The second proband presented mainly with peripheral neuropathy, and genetic analysis of the ...
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