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Article: Differential Uptake of O-(2-^sup 18^F-Fluoroethyl)-L-Tyrosine, L-^sup 3^H-Methionine, and ^sup 3^H-Deoxyglucose in Brain Abscesses
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- December 1, 2007
- Author:
CopyrightCopyright Society of Nuclear Medicine Dec 2007. Provided by ProQuest LLC. (Hide copyright information)
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The amino acid O-(2-^sup 18^F-fluoroethyl)-L-tyrosine (^sup 18^F-FET) has been shown to be a useful tracer for brain tumor imaging. Experimental studies demonstrated no uptake of ^sup 18^F-FET in inflammatory cells but increased uptake has been reported in single cases of human brain abscesses. To explore this inconsistency, we investigated the uptake of ^sup 18^F-FET in comparison with that of L-[methyl-^sup 3^H]methionine (^sup 3^H-MET) and D-^sup 3^H-deoxyglucose (^sup 3^H-DG) in brain and calf abscesses in rats. Methods: Abscesses were induced in the brain (n = 9) and calf (n = 5) of Fisher CDF rats after inoculation of Staphylococcus aureus. Five days later, ^sup 18^F-FET and ^sup ...