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Article: Efficacy of Antioxidant Supplementation in Reducing Primary Cancer Incidence and Mortality: Systematic Review and Meta-analysis
- Article from:
- Mayo Clinic Proceedings
- Article date:
- January 1, 2008
- Author:
CopyrightCopyright Mayo Foundation for Medical Education and Research Jan 2008. Provided by ProQuest LLC. (Hide copyright information)
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OBJECTIVE: To estimate the association between antioxidant use and primary cancer incidence and mortality and to evaluate these effects across specific antioxidant compounds, target organs, and participant subgroups.
METHODS: Multiple electronic databases (MEDLINE, Cochrane Controlled Clinical Trials Register, EMBASE, Science Citation Index) were searched from their dates of inception until August 2005 to identify eligible randomized clinical trials. Random effects meta-analyses estimated pooled relative risks (RRs) and 95% confidence intervals (CIs) that described the effect of antioxidants vs placebo on cancer incidence and cancer mortality.
RESULTS: Twelve eligible trials, 9 of high ...