Article: Quantification of Cerebral Blood Flow and Oxygen Metabolism with 3-Dimensional PET and ^sup 15^O: Validation by Comparison with 2-Dimensional PET

Quantitative PET with ^sup 15^O provides absolute values for cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral metabolic rate of oxygen (CMRO^sub 2^), and oxygen extraction fraction (OEF), which are used for assessment of brain pathophysiology. Absolute quantification relies on physically accurate measurement, which, thus far, has been achieved by 2-dimensional PET (2D PET), the current gold standard for measurement of CBF and oxygen metabolism. We investigated whether quantitative ^sup 15^O study with 3-dimensional PET (3D PET) shows the same degree of accuracy as 2D PET. Methods: 2D PET and 3D PET measurements were obtained on the same day on 8 healthy men (age, 21-24 y). ...

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