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Article: ^sup 99m^Tc-GSA Scintigraphy with SPECT for Assessment of Hepatic Function and Functional Volume During Liver Regeneration in a Rat Model of Partial Hepatectomy
- Article from:
- The Journal of Nuclear Medicine
- Article date:
- January 1, 2008
- Author:
CopyrightCopyright Society of Nuclear Medicine Jan 2008. Provided by ProQuest LLC. (Hide copyright information)
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Small-animal models are crucial to gain insights in the complex recovery mechanisms of liver function during liver regeneration. ^sup 99m^Tc-Mebrofenin hepatobiliary scintigraphy (HBS) has been introduced for noninvasive assessment of liver function in the clinical setting as well as in experimental research. However, HBS is restricted to planar modalities in small animals because hepatic kinetics are generally too fast for SPECT acquisition. ^sup 99m^Tc-DTPA-galactosyl serum albumin (where DTPA is diethylenetriaminepentaacetic acid) (^sup 99m^Tc-GSA) scintigraphy is an alternative, receptor-mediated, noninvasive liver function test. After hepatic uptake, ^sup 99m^Tc-GSA remains trapped in ...